Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 30, Issue -, Pages S131-S134Publisher
ELSEVIER
DOI: 10.1016/j.ijantimicag.2007.07.038
Keywords
amoxicillin/clavulanate; respiratory tract infection; pharmacokinetics; pharmacodynamics; dosing regimen
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Rising levels of resistance amongst the major respiratory pathogens have compromised empiric antimicrobial therapy. This, coupled with a recent lack in availability of novel classes of antibacterials, has led to a need for new approaches to combat community respiratory tract infections. Bacteriological and clinical efficacy in two trials involving patients with acute bacterial sinusitis and six trials of patients with community-acquired pneumonia has shown that the development of a pharmacokinetically enhanced formulation of amoxicillin/clavulanate (Augmentin SR, available as Augmentin XR in the USA) has allowed amoxicillin/clavulanate to retain its place in the treatment of respiratory tract infections today. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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