Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 11, Issue 6, Pages 612-619Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2007.10.004
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Funding
- NIGMS NIH HHS [R01 GM074070, R01 GM074070-02, GM074070] Funding Source: Medline
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A major goal of synthetic biology is to reprogram bacteria to carry out complex tasks, such as synthesizing and delivering drugs, and seeking and destroying environmental pollutants. Advances in molecular biology and bacterial genetics have made it straightforward to modify, insert, or delete genes in many bacterial strains, and advances in gene synthesis have opened the door to replacing entire genomes. However, rewriting the underlying genetic code is only part of the challenge of reprogramming cellular behavior. A remaining challenge is to control how and when the modified genes are expressed. Several recent studies have highlighted how synthetic riboswitches, which are RNA sequences that undergo a ligand-induced conformational change to alter gene expression, can be used to reprogram how bacteria respond to small molecules.
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