Journal
NATURE REVIEWS IMMUNOLOGY
Volume 7, Issue 12, Pages 954-963Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2187
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Funding
- MRC [G0401620] Funding Source: UKRI
- Medical Research Council [G0401620] Funding Source: researchfish
- Medical Research Council [G0401620] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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alpha beta T cells pass through a series of lymphoid tissue stromal microenvironments to acquire self tolerance and functional competence. In the thymus, positive selection of the developing T-cell receptor repertoire occurs in the cortex, whereas events in the medulla purge the system of self reactivity. T cells that survive are exported to secondary lymphoid organs where they direct first primary and then memory immune responses. This Review focuses on the microenvironments that nurture T-cell development rather than on T cells themselves. We summarize current knowledge on the formation of thymic epithelial-cell microenvironments, and highlight similarities between the environments that produce T cells and those that select and maintain them during immune responses.
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