Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 84, Issue 2, Pages 4-11Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2011.09-0498
Keywords
-
Funding
- World Health Organization Initiative for Vaccine Research [LA35735G]
- National Institute of Allergy and Infectious Diseases (NIAID) [49486/TMRC]
- Colombian National Research Council
- COLCIENCIAS
- Ministry for Social Protection [253-2005, 207-2007]
- Malaria Vaccine and Drug Development Center Foundation
Ask authors/readers for more resources
A safe and reproducible Plasmodium vivax infectious challenge method is required to evaluate the efficacy of malaria vaccine candidates. Seventeen healthy Duffy (+) and five Duffy (-) subjects were randomly allocated into three (A-C) groups and were exposed to the bites of 2-4 Anopheles albimanus mosquitoes infected with Plasmodium vivax derived from three donors. Duffy (-) subjects were included as controls for each group. Clinical manifestations of malaria and parasitemia were monitored beginning 7 days post-challenge. All Duffy (+) volunteers developed patent malaria infection within 16 days after challenge. Prepatent period determined by thick smear, was longer for Group A (median 14.5 d) than for Groups B and C (median 10 d/each). Infected volunteers recovered rapidly after treatment with no serious adverse events. The bite of as low as two P vivax-infected mosquitoes provides safe and reliable infections in malaria-naive volunteers, suitable for assessing antimalarial and vaccine efficacy trials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available