Journal
NANO LETTERS
Volume 7, Issue 12, Pages 3818-3821Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl072471q
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Funding
- NCI NIH HHS [U54 CA119341] Funding Source: Medline
- NIH HHS [DP1 OD000285] Funding Source: Medline
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The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated Ali the particle.
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