Journal
EXPERT REVIEW OF PROTEOMICS
Volume 4, Issue 6, Pages 757-767Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1586/14789450.4.6.757
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In the last few years, a growing interest has arisen in the application of proteomic analysis to rheumatic disease. Sjogren's syndrome is a systemic disease that affects exocrine glands directly, and is therefore expected to influence the composition of the whole human saliva and lachrymal fluid. Therefore, a rising number of studies have been performed in an attempt to characterize the salivary and lachrymal protein profiles of patients with Sjogren's syndrome by using a proteomic approach. This review summarizes the state of the art and the potential application of proteomics in the systematic search for diagnostic biomarkers in Sjogren's syndrome.
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