Plasma levels of 15-F2t-isoprostane in newborn infants are affected by mode of delivery

Objective: To investigate how the mode of delivery affects the level oxidative stress in newborns. Design and methods: 15-F-2t-isoprostane,as index of oxidative stress, was measured in umbilical cord plasma samples from 37 infants born after vaginal delivery or caesarian section, using specific immuno-affinity extraction and immunoassay. Results: 15-F-2t-isoprostane levels were higher in infants born after vaginal delivery (n = 18) compared to those delivered by elective caesarian section (n = 19). Conclusions: 15-F-2t-isoprostane is a sensitive biomarker of fetal oxidative stress during labor. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.