Journal
MATHEMATICAL BIOSCIENCES
Volume 210, Issue 2, Pages 576-597Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mbs.2007.07.001
Keywords
malaria; Stochastic; infection; disease; immunity; transmission
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Funding
- FIC NIH HHS [R01 TW001543, R01 TW001543-05S1] Funding Source: Medline
- Intramural NIH HHS [Z99 TW999999] Funding Source: Medline
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We develop a simple three-state stochastic description of individual malaria infections that relates dynamics of disease and immune status to age and previous exposure, under different intensities of transmission. We apply the resulting individual-based community models to examine the effects of drug treatment and vaccination on the frequency and severity of disease in ensembles of children. The several broad qualitative similarities between our results and field observations include potential rebound effects following intervals of drug treatment. (C) 2007 Elsevier Inc. All rights reserved.
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