Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 82, Issue 5, Pages 961-966Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.09-0689
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Funding
- National Natural Science Foundation of China [30570063]
- 863 National High Technology Research and Development Program of China [2006A A02Z453]
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Hepatitis E is a worldwide public health problem, especially in areas with poor Sanitation. This study examines the potential hepatitis E virus (HEV) animal reservoirs and the current status of HEV infection among animals and humans in an endemic area of Xinjiang, China. One thousand five hundred twenty-one serum samples from 12 different animal species and 296 sera from humans were detected for anti-HEV with an in-house enzyme immunoassay, and partial HEV RNA was amplified with a reverse transcription nested polymerase chain reaction (RT-nPCR). All these distinct animal species, except jerboa and hoptoad, were positive for anti-HEV. However, HEN RNA was only amplified from pigs and a sporadic hepatitis E case in humans. The human HEV strain (CHN-XJ-HE29) shared 100% nucleotide identity with the swine HEV strain (CHN-XJ-SW50). both of which were collected from the same district: this indicates the possibility of HEV transmission from swine to humans in an endemic area.
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