Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 10, Issue 6, Pages 520-527Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2007.10.005
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Funding
- Medical Research Council [G120/1001] Funding Source: researchfish
- Medical Research Council [G120/1001] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G120/1001] Funding Source: UKRI
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The process of cytokinesis, where the cytoplasm of one cell is divided to produce two daughter cells, is intricate in trypanosomatids because of the requirement to replicate and segregate a number of single copy organelles, including the nucleus, kinetoplast, Golgi apparatus, and flagellum. Identifying regulators of the three stages of cytokinesis, initiation, furrow ingression, and abscission is complicated by the fact that cell division in trypanosomatids is easily perturbed and aberrant cells are readily produced during functional characterization of gene products. In this review, we discuss direct and indirect effects on cytokinesis, using Trypanosoma brucei as a model.
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