Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 83, Issue 2, Pages 357-364Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.10-0156
Keywords
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Funding
- Medecins Sans Frontieres
- Operational Centre Barcelona-Athens
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We evaluated, through the prospective monitoring of 251 patients at Sadai Hospital in Bihar, India. the effectiveness and safety of 20 mg/kg body weight of liposomal amphotericin B for the treatment of visceral leishmaniasis The treatment success rates for the intention-to-treat. per protocol, and intention-to-treat worse-case scenario analyses were 98 8%. 99 6%. and 81 3%. respectively Nearly one-half of patients experienced mild adverse events. but only 1% developed serious but non-Me-threatening lips swelling The lost to follow-up rate was 17.5% Our findings indicate that the 20 mg/kg body weight treatment dosage is effective and safe under routine program conditions Given that the exorbitant cost of liposomal amphotericin B is a barrier to its widespread use, we recommend further study to monitor and evaluate a lowered dosage and a shorter treatment course
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