Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 83, Issue 1, Pages 115-121Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.09-0684
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Funding
- Institut de Recherche pour le Developpement (IRD) (Departement Soutien et Formation)
- Research Ministry of France
- Francois Lacoste
- Inkerman Foundation
- Acer-Energy (ACERGY)-Societe Nationale de Metallurgic (SONAMET) Company
- French Ministry of Defense (Delegation Generale pour l'Armement, DGA)
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For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.
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