Journal
NATURE METHODS
Volume 4, Issue 12, Pages 1003-U8Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth1134
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Funding
- NIGMS NIH HHS [R01 GM073046-03, R01 GM073046] Funding Source: Medline
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Analysis of gene function in apicomplexan parasites is limited by the absence of reverse genetic tools that allow easy and rapid modulation of protein levels. The fusion of a ligand-controlled destabilization domain (ddFKBP) to a protein of interest enables rapid and reversible protein stabilization in T. gondii. This allows an efficient functional analysis of proteins that have a dual role during host cell invasion and/or intracellular growth of the parasite.
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