Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 83, Issue 2, Pages 416-421Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.09-0700
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One small previous study found that praziquantel reduced hookworm infection In this study, 607 subjects were enrolled in a longitudinal study At enrollment and every 3 months for 18 months, three stool samples were collected. and the intensity of infection with Schistosoma japonicum and soil-transmitted helminths (STHs) was quantified. All subjects were treated with 60 mg/kg praziquantel at baseline. Three months post-treatment, the percent of subjects who were hookworm-infected decreased to 46 5% from 61% at baseline The putative cute late was 23 7% The 95% confidence interval around the change in hookworm egg counts from baseline to 6 and 12 months post-treatment was negative and did not include zero The percent reduction in hookworm egg counts from baseline to 3 months post-treatment was 40 8% Praziquantel treatment did not decrease the infection intensity of STHs Control programs using praziquantel may have the added benefit of reducing hookworm infection and anemia in areas of coendemnicity
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