Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 121, Issue 11, Pages 2373-2380Publisher
WILEY
DOI: 10.1002/ijc.23173
Keywords
inflammation; microRNA; nitric oxide; cancer
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Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e-g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post-translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer. (C) 2007 Wiley-Liss, Inc.
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