Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 81, Issue 1, Pages 108-115Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2009.81.108
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Funding
- Secretaria de Vigilancia em Sadde/Ministerio da Saude
- Programa de Desenvolvimento e Inovacao Tecnologica em Saude Publica/Fundacao Oswaldo Cruz
- Vice-Presidencia de Servicos de Referencia e Ambiente/Fundacao Oswaldo Cruz
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Financiadora de Estudos e Projetos do Rio de Janeiro
- Howard Hughes Medical Institute
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The nature of pyrethroid resistance in Aedes aegypti Brazilian populations was investigated. Quantification of enzymes related to metabolic resistance in two distinct populations, located in the Northeast and Southeast regions, revealed increases in Glutathione-S-transferase (GST) and Esterase levels. Additionally, polymorphism was found in the IIS6 region of Ae. aegypti voltage-gated sodium channel (AaNa(v)), the pyrethroid target site. Sequences were classified in two haplotype groups, A and B, according to the size of the intron in that region. Rockefeller, a susceptible control lineage, contains only B sequences. In field populations, some A sequences present a substitution in the 1011 site (Ile/Met). When resistant and susceptible individuals were compared, the frequency of both A (with the Met mutation) and B sequences were slightly increased in resistant specimens. The involvement of the AaNa(v) polymorphism in pyrethroid resistance and the metabolic mechanisms that lead to potential cross-resistance between organophosphate and pyrethroids are discussed.
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