Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 10, Issue 6, Pages 578-581Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2007.10.004
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Dictyostelium is one of the most successful and best-studied organisms for research into the mechanisms that drive chemotaxis. In this review, we discuss recent progress in the field. Phosphatidylinositol 3-kinase (PI 3-kinase), previously thought by some to be essential for chernotaxis, has now been proven to be dispensable. However, other pathways are emerging which might connect signalling to migration. In particular, phospholipase A2 homologues appear to play an important role. Other areas of current interest include the fundamental processes by which cells move - pseuclopods have been found to be generated in many different ways. Similarly, chernotaxis may be mediated by multiple checks on the number of pseuclopods, rather than by simple generation of new pseuclopods on demand. Finally, we review several advances in the theory of how cells convert shallow, noisy chemical gradients into overt movement.
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