Journal
LEARNING & MEMORY
Volume 14, Issue 12, Pages 816-820Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.781507
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Funding
- NCRR NIH HHS [P51 RR000165, P51RR000165] Funding Source: Medline
- NIDA NIH HHS [R01 DA019624-01A2, R01 DA019624, DA-019624] Funding Source: Medline
- NIMH NIH HHS [K01 MH069884, MH069884, R37 MH47840, R37 MH047840] Funding Source: Medline
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We examined brain-derived neurotrophic factor (BDNF) mRNA expression across the olfactory system following fear conditioning. Mice received 10 pairings of odor with footshock or equivalent unpaired odors and shocks. We found increased BDNF mRNA in animals receiving paired footshocks in the multiple regions examined including the posterior piriform cortex (PPC) and basolateral amygdala (BLA). This was in contrast to the unpaired and odor- alone treatments, where BDNF mRNA was increased in the olfactory bulb (OB) and anterior piriform cortex (APC) only, but not the higher olfactory areas. We propose that odor exposure increases expression of BDNF in the OB and APC while the PPC and BLA increase BDNF mRNA only when associative learning occurs.
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