Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 18, Issue 6, Pages 743-750Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.09.007
Keywords
ER-associate degradation; ER quality control; ERAD; EDEM; Htm1p; Yos9p; misfolded proteins; lectin; N-linked glycosylation
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Protein quality control pathways monitor the folding of newly synthesized proteins throughout the cell. Irreversibly misfolded proteins are sorted and degraded to neutralize their potential toxicity. In the secretory pathway, multiple strategies have evolved to test the wide diversity of molecules that traffic through the endoplasmic reticulum. The organelle has adapted the use of N-linked glycans to signal protein folding states. The signals are read by the EDEM and Yos9 protein families that take substrates out of folding cycles for degradation. (C) 2007 Elsevier Ltd. All rights reserved.
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