Journal
GENETICS
Volume 177, Issue 4, Pages 2251-2261Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.107.080663
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Funding
- Biotechnology and Biological Sciences Research Council [BB/D015480/1] Funding Source: researchfish
- BBSRC [BB/D015480/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D015480/1] Funding Source: Medline
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The distribution of fitness effects of new mutations (DFE) is important for addressing several questions in genetics, including the nature of quantitative variations and the evolutionary fate of small populations. Properties of the DFE can be inferred by comparing the distributions of the frequencies of segregating nucleotide polymorphisms at selected and neutral sites in a population sample, but demographic changes alter the spectrum for. We have developed a maximum-likelihood approach, based on the expected allele-frequency distribution generated by transition matrix methods, to estimate parameters of the DFE while simultaneously estimating parameters of a demographic model that allows a populations size change at some time in the past. We tested the method using simulations and found that it accurately recovers simulated parameters values, even if the simulated demography differs substantially from that assumed in our analysis. We use our method to estimate parameters of the DFE for amino acid-changing mutations in humans and Drosophila melanogaster. For a model of unconditionally deleterious mutations, with effects sampled from a gamma distribution, the mean estimate for the distribution shape parameter is similar to 0.2 for human populations, which implies that the DFE is strongly leptokurtic. For Drosophila populations, we estimate that the shape parameter is similar to 0.35. Differences in the shape of the distribution and the mean selection coefficient between humans and Drosophila result in significantly more strongly deleterious mutations in Drosophila than in humans, and, conversely, nearly neutral mutations are significantly less frequent.
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