Journal
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Volume 78, Issue 12, Pages 1375-1378Publisher
B M J PUBLISHING GROUP
DOI: 10.1136/jnnp.2006.114231
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Funding
- NCRR NIH HHS [M01 RR000079, M01-RR00079, M01 RR000079-32] Funding Source: Medline
- NIA NIH HHS [P01 AG019724-030002, K08-AG020760-01, K08 AG020760-01, K08 AG027086, P01 AG019724, P50-AG023501, R01 AG022983-05, K08 AG027086-01, P50 AG023501-010002, P50 AG023501, R01-AG022983, R01 AG022983, K08 AG020760, P01-AG1972403, K08-AG027086-01] Funding Source: Medline
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We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo.
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