Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 12, Pages 1910-1914Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0703904
Keywords
-
Ask authors/readers for more resources
In a screening study for natural products with tumor-selective apoptosis-inducing properties, six new isoflavonoids (1-6), named brandisianins A-F, respectively, have been isolated from a MeOH extract of the dried leaves of Millettia brandisiana, together with five known compounds. The structures of the new compounds were elucidated by spectroscopic data interpretation. Among these compounds, brandisianin D (4) exhibited death-receptor 5 expression enhancement activity in a luciferase assay based in DLD-1/SacI cells. The results suggest that brandisianin D (4) might overcome TRAIL-resistance by an increase in DR5 expression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available