Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 40, Issue 12, Pages 1367-1376Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar700100e
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This Account gives an overview of the homogeneously catalyzed asymmetric hydrogenation of prochiral amino ketones. The preparation of enantiopure arylalkanolamines, which are potent and economically very important pharmaceuticals, is described. Classical routes of synthesis are compared with the new asymmetric hydrogenation route for a number of compounds from the viewpoint of an industrial pharmaceutical chemist.
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