Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 18, Issue 6, Pages 770-779Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.09.002
Keywords
endoplasmic reticulum-associated degradation; ubiquitin protein ligase (E3); proteasome; Saccharomyces cerevisiae
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Funding
- Intramural NIH HHS [Z01 BC009392-13] Funding Source: Medline
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Endoplasmic reticulum-associated degradation (ERAD) represents the primary means of quality control within the secretory pathway. Critical to this process are ubiquitin protein ligases (E3s) which, together with ubiquitin conjugating enzymes (E2s), mediate the ubiquitylation of proteins targeted for degradation from the ER. In this chapter we review our knowledge of both Saccharomyces cerevisiae and mammalian ERAD ubiquitin ligases. We focus on recent insights into these E3s, their associated proteins and potential mechanisms of action. Published by Elsevier Ltd.
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