Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 15, Issue 6, Pages 701-707Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1472-6483(10)60538-X
Keywords
blastocyst; hyaluronan; single blastocyst transfer; single embryo transfer
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The purpose of this prospective randomized study was to evaluate use of a hyaluronan-rich transfer medium in fresh and frozen-thawed single blastocyst transfer. The study included 279 single blastocyst transfers in women aged <37 years in their first, second or third treatment cycle. According to the type of single blastocyst transfer (fresh elective or frozen-thawed) the women were divided into two study and two control groups. In both study groups (n = 130) transfers were performed using hyaluronan and in the control groups (n = 149) a conventional transfer medium was used. The results indicate that fresh elective single blastocyst transfer with hyaluronan results in significantly higher pregnancy rates in a selected subgroup of women; those with >= 2 blastocysts developed to day 5 and a previous implantation failure (55% versus 10%; P = 0.012). Overall pregnancy rates after fresh elective and frozen-thawed single blastocyst transfer were similar in both study and control groups.
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