Journal
BIOMATERIALS
Volume 28, Issue 34, Pages 5185-5192Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.07.044
Keywords
hydrogels; smart biomaterials; self-assembly; hybrid biomaterials; bionanotechnology
Funding
- NIBIB NIH HHS [EB005288, EB00251, R01 EB005288-03, R01 EB000251-07, R01 EB005288] Funding Source: Medline
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Hydrogels were the first biomaterials developed for human use. The state-of-the-art and potential for the future are discussed. Recently, new designs have produced mechanically strong synthetic hydrogels. Protein-based hydrogels and hybrid hydrogels containing protein domains present a novel advance; such biomaterials may self-assemble from block or graft copolymers containing biorecognition domains. One of the domains, the coiled coil, ubiquitously found in nature, has been used as an example to demonstrate the developments in the design of smart hydrogels. The application potential of synthetic, protein based, DNA based, and hybrid hydrogels bodes well for the future of this class of biomaterials. (C) 2007 Elsevier Ltd. All rights reserved.
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