Journal
BRITISH JOURNAL OF ANAESTHESIA
Volume 99, Issue 6, Pages 775-786Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bja/aem316
Keywords
analgesics non-opioid, gabapentin; pain, chronic; premedication, anxiolysis; reflexes, laryngeal; vomiting, nausea
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Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain. It was not, until recently, thought to be useful in acute perioperative conditions. However, a growing body of evidence suggests that perioperative administration is efficacious for postoperative analgesia, preoperative anxiolysis, attenuation of the haemodynamic response to laryngoscopy and intubation, and preventing chronic post-surgical pain, postoperative nausea and vomiting, and delirium. This article reviews the clinical trial data describing the efficacy and safety of gabapentin in the setting of perioperative anaesthetic management.
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