Two patterns of daily hypoxic exposure and their effects on measures of chemosensitivity in humans

Two patterns of daily hypoxic exposure and their effects on measures of chemosensitivity in humans. J Appl Physiol 103: 1973-1978, 2007. First published October 18, 2007; doi:10.1152/japplphysiol.00545.2007.-The purpose of this study was to compare chemoresponses following two different intermittent hypoxia ( IH) protocols in humans. Ten men underwent two 7-day courses of poikilocapnic IH. The long-duration IH ( LDIH) protocol consisted of daily 60-min exposures to normobaric 12% O-2. The short-duration IH ( SDIH) protocol comprised twelve 5-min bouts of 12% O2, separated by 5-min bouts of room air, daily. Isocapnic hypoxic ventilatory response ( HVR) was measured daily during the protocol and 1 and 7 days following. Hypercapnic ventilatory response ( HCVR) and CO2 threshold and sensitivity ( by the modified Read rebreathing technique) were measured on days 1, 8, and 14. Following 7 days of IH, the mean HVR was significantly increased from 0.47 +/- 0.07 and 0.47 +/- 0.08 to 0.70 +/- 0.06 and 0.79 +/- 0.06 l center dot min(-1)center dot% Sa(O2)(-1) ( LDIH and SDIH, respectively), where % Sa(O2) is percent arterial oxygen saturation. The increase in HVR reached a plateau after the third day. One week post-IH, HVR values were unchanged from baseline. HCVR increased from 3.0 +/- 0.4 to 4.0 +/- 0.5 l center dot min(-1)center dot mmHg(-1). In both the hyperoxic and hypoxic modified Read rebreathing tests, the slope of the CO2/ventilation plot was unchanged by either intervention, but the CO2/ventilation curve shifted to the left following IH. There were no correlations between the changes in response to hypoxia and hypercapnia. There were no significant differences between the two IH protocols for any measures, indicating that comparable changes in chemoreflex control occur with either protocol. These results also suggest that the two methods of measuring CO2 response are not completely concordant and that the changes in CO2 control do not correlate with the increase in the HVR.