Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 15, Issue 1, Pages 39-43Publisher
WILEY-BLACKWELL
DOI: 10.1111/ajt.13028
Keywords
B cell biology; cellular biology; editorial; personal viewpoint; immune regulation; immunobiology; immunosuppression; immune modualtion; lymphocyte biology; plasma cells
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B cells play a complex role in the immune response. In addition to giving rise to plasma cells (PCs) and promoting T cell responses via antigen presentation, they perform immunoregulatory functions. This knowledge has created concerns regarding nonspecific B cell depletional therapy because of the potential to paradoxically augment immune responses. Recent studies now indicate that PCs have immune functions beyond immunoglobulin synthesis. Evidence for a new role for PCs as potent regulatory cells (via IL-10 and IL-35 production) is discussed including the implications for PC-targeted therapies currently being developed for clinical transplantation. In this new feature, the authors discuss the recent article IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases (Nature 2014; 507: 366-370) and its implications for transplantation.
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