Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 7, Issue 12, Pages 2826-2828Publisher
WILEY
DOI: 10.1111/j.1600-6143.2007.01994.x
Keywords
Cellulitis; cryptococcosis; immune reconstitution inflammatory syndrome; renal allograft transplant
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Immune reconstitution inflammatory syndrome (IRIS) has rarely been described in the course of disseminated cryptococcosis in solid organ transplant recipients. We report here the case of a renal transplant recipient who developed severe cellulitis in the context of Cryptococcus neoformans-associated IRIS while undergoing reduction of his immunosuppressive therapy. IRIS appeared concomitantly with a dramatic increase of blood CD4+ T cells (94-460/mm(3)) and required the administration of a short-term steroid therapy to resolve.
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