Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 13, Issue 3, Pages 541-551Publisher
WILEY-BLACKWELL
DOI: 10.1111/ajt.12089
Keywords
Coinhibition; costimulation; HVEM; LIGHT; LT R; transplantation
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Funding
- Ministry of Health and Department of Education from Junta of Castilla [PI10/01039]
- Swiss National Science Foundation
- [LE007A10-2]
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The exchange of information during interactions of T cells with dendritic cells, B cells or other T cells regulates the course of T, B and DC-cell activation and their differentiation into effector cells. The tumor necrosis factor superfamily member LIGHT (homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T lymphocytes) is transiently expressed upon T cell activation and modulates CD8 T cell-mediated alloreactive responses upon herpes virus entry mediator (HVEM) and lymphotoxin receptor (LTR) engagement. LIGHT-deficient mice, or WT mice treated with LIGHT-targeting decoy receptors HVEM-Ig, LTR-Ig or sDcR3-Ig, exhibit prolonged graft survival compared to untreated controls, suggesting that LIGHT modulates the course and severity of graft rejection. Therefore, targeting the interaction of LIGHT with HVEM and/or LTR using recombinant soluble decoy receptors or monoclonal antibodies represent an innovative therapeutic strategy for the prevention and treatment of allograft rejection and for the promotion of donor-specific tolerance.
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