Journal
JOURNAL OF ANTIBIOTICS
Volume 60, Issue 12, Pages 757-761Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2007.100
Keywords
pyranonaphthoquinone; griseusin D; alkaphilic Nocardiopsis sp.
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A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5'-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed strong cytotoxicity against human leukemia cells (HL60) and modest cytotoxicity against human lung adenocarcinoma cell lines (AGZY) with IC50 values of 0.23 and 19.6 mu g/ml, respectively. It also exhibited weak antifungal activity against Alternaria alternate with MIC of 140 mu g/ml.
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