Journal
ELECTROANALYSIS
Volume 19, Issue 23, Pages 2428-2436Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.200703968
Keywords
penicillamine; tyrosinase; nano-Au; PAMAM; catechol; biosensor
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Funding
- National Research Foundation of Korea [과06A1506] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Gold electrodes were modified with submonolayers of 3-mercaptopropionic acid and further reacted with poly(amidoamine) (PAMAM) dendrimers to obtain thin films. The high affinity of PAMAM dendrimer for nano-Au with its amine groups was used to realize the role of nano-Au as an intermediator to immobilize the enzyme of tyrosinase. The characterization of the modified electrode was investigated by cyclic voltammetry, electrochemical impedance spectroscopy and atomic force microscopy (AFM). Tyrosinase can catalyze the oxidation of catechol to o-benzoquinone. When penicillamine was added to the solution, it reacted with o-benzoquinone to form the corresponding thioquinone derivatives, which resulted in decrease of the reduction current of o-benzoquinone. Based on this, a new electrochemical sensor for determination of penicillamine has been developed.
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