Journal
MOLECULAR ONCOLOGY
Volume 1, Issue 3, Pages 350-355Publisher
WILEY
DOI: 10.1016/j.molonc.2007.08.005
Keywords
Human papillomavirus; Tonsillar carcinoma; Head and neck squamous; cell carcinoma; Viral load; E6 mRNA; E7 mRNA
Categories
Funding
- Swedish Cancer Foundation
- The Stockholm Cancer Society
- The Swedish Research Council
- The Laryngeal Foundation
- Stockholm City Council
- Karolinska Institutet
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From 1970 to 2002 in the Stockholm area, we revealed a parallel three-fold increase in the incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases, indicating a possible role of HPV infection in this disease. We have now examined whether HPV and viral load in pre-treatment tonsillar cancer biopsies correlates to disease prognosis, and whether the presence of HPV-16 E6 and E7 mRNA could be ascertained. The presence of HPV-16, but not viral load, in tonsillar cancer was shown to be a favourable prognostic factor for clinical outcome. Moreover, E6 and/or E7 were expressed in almost all assessable HPV-16 positive cases, supporting an oncogenic role of HPV-16 in tonsillar cancer. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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