Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 192, Issue 1-2, Pages 40-48Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.09.003
Keywords
microglia; spinal cord; OX-42; cyclooxygenase; inflammation; formalin
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Funding
- NINDS NIH HHS [P01 NS039420-05, P01 NS039420, P01-NS039429, P01 NS039420-050001] Funding Source: Medline
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We compared the effects of peripheral Freund's Complete Adjuvant (CFA) and formalin injection on spinal microglia activation. Both qualitative and quantitative analyses showed signs of microglia activation on the ipsilateral side of the lumbar dorsal horn on day 3, day 7 and day 14 after formalin injection. However, significant microglia morphological alteration was not found in the CFA model. At the injection site in the paw, CFA injection induced considerably more inflammation than formalin injection. Although spinal microglia might be activated in inflammatory pain models, morphologically, spinal microglia activation was not closely correlated with peripheral inflammation. (c) 2007 Elsevier B.V All rights reserved.
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