4.3 Review

New targets and emerging therapies for reducing LDL cholesterol

Journal

CURRENT OPINION IN LIPIDOLOGY
Volume 18, Issue 6, Pages 650-655

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0b013e3282f169c6

Keywords

apolipoprotein B; LDL-cholesterol; microsomal triglyceride transfer protein; proprotein convertase subtilisin kexin type 9; squalene synthase

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The emergence of modalities that act in series and in parallel with available agents may allow more effective LDL-cholesterol lowering in those patients intolerant of current therapy, and may permit clecremental reductions in LDL-cholesterol for those unable to achieve aggressive LDL-cholesterol goals using existing agents.

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