Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 13, Issue 1, Pages 36-44Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-6143.2012.04283.x
Keywords
Alloimmunity; leptin; regulatory T cell; tolerance
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Funding
- State of Sao Paulo Foundation for Research Support (FAPESP) [07/07139-3, 08/55447-1, 09/50450-7, 08/58564-9, 10/52180-4, 12/02270-2]
- International Associated Laboratory in Renal Immune RegulationImmuneregulation (CNPq/Inserm)
- Brazilian Council of Scientific and Technologic Development [470533/2007-2]
- Brazilian Council of Scientific and Technologic Development (CNPq/DECIT/MS)
- Complex Fluids INCT
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/50450-7] Funding Source: FAPESP
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Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lepob/ob and wild-type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.
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