Journal
APPLIED & PREVENTIVE PSYCHOLOGY
Volume 12, Issue 3, Pages 140-148Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.appsy.2007.09.003
Keywords
schizophrenia; attention; inhibition; priming; schizotypal personality; spatial
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Funding
- NIDA NIH HHS [R21 DA019672-01, R21 DA019672] Funding Source: Medline
- NIMH NIH HHS [R01 MH073028, R01 MH073028-02] Funding Source: Medline
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One of the core deficits that characterizes schizophrenia is an increase in distractibility and disinhibition at all levels of information processing. Patients with schizophrenia seem unable to focus attention on the relevant events while ignoring the irrelevant stimuli. This pattern of behavior is also observed in unmedicated schizotypal individuals who may carry liability for schizophrenia. In this review, we focus on studies of attentional inhibition, as assessed by the negative priming paradigm, to elucidate the relationships among deficits in inhibition, clinical symptoms and medication effects. We then consider models of the etiology of deficits in negative priming in schizophrenia and schizotypal personality. Finally, we discuss the potential power of utilizing hypothesis-driven cognitive paradigms in psychiatric research. (C) 2007 Elsevier Ltd. All rights reserved.
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