Journal
MAGNETIC RESONANCE IMAGING
Volume 25, Issue 10, Pages 1437-1441Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2007.04.006
Keywords
magnetic nanoparticles; ferrofluids; NMR contrast agents
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Physicochemical and magnetorelaxometric characterization of the colloidal suspensions consisting of Fe-based nanoparticles coated with dextran have been carried out. Iron oxide and iron core/iron oxide shell nanoparticles were obtained by laser-induced pyrolysis of Fe(CO)(5) vapours. Under different magnetic field strengths, the colloidal suspension formed by iron oxide nanoparticles showed longitudinal (R-2) and transverse (R-2) nuclear magnetic relaxation suspension (NMRD) profiles, similar to those previously reported for other commercial magnetic resonance imaging (MRI) contrast agents. However, colloidal suspension formed by ferromagnetic iron-core nanoparticles showed a strong increase of the R-1 values at low applied magnetic fields and a strong increase of the R-2 measured at high applied magnetic field. This behaviour was explained considering the larger magnetic aggregate size and saturation magnetization values measured for this sample, 92 nm and 31 emu/g Fe, respectively, with respect to those measured for the colloidal suspensions of iron oxide nanoparticles (61 nm and 23 emu/g Fe). This suspension can be used both as T-1 and T-2 contrast agent. (c) 2007 Elsevier Inc. All rights reserved.
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