Journal
INTERNATIONAL DAIRY JOURNAL
Volume 17, Issue 12, Pages 1473-1477Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.idairyj.2007.04.009
Keywords
kappa-casein macropeptide; vascular effects; antihypertensive properties; bioactive peptides
Categories
Ask authors/readers for more resources
The blood-pressure-lowering effect of bovine K-casein macropeptide (CMP), previously reported to exhibit a modest angiotensin-converting enzyme (ACE)-inhibitory activity in vitro, was evaluated in spontaneously hypertensive rats (SHR). The oral administration of CMP (150 mg kg(-1)) significantly reduced the systolic blood pressure (SBP) of SHR. The anti hypertensive action was more pronounced when CMP was treated with trypsin. The sequence MAIPPKK, identified in the tryptic hydrolysate of bovine CMP, significantly reduced blood pressure at a dose of 10mgkg(-1). The CMP and its tryptic peptides induced relaxation of endothelium-intact aortic rings. The sequence MAIPPKK also evoked a significant relaxation effect; however, the shorter sequence MAIPPK and the strong ACE-inhibitory tripeptide IPP exhibited a vascular relaxing effect lower than 10%. The implications of vascular relaxing mechanisms, as well as the possibility that the tripeptide IPP is at least partially responsible for the antihypertensive effects of CMP, are discussed. (C) 2007 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available