Journal
PLOS GENETICS
Volume 3, Issue 12, Pages 2395-2403Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.0030215
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Funding
- NIGMS NIH HHS [R01 GM034028, GM34028, R01 GM067031, 5F32GM065721-02, GM067031, F32 GM065721] Funding Source: Medline
- Wellcome Trust [061641] Funding Source: Medline
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MicroRNAs ( miRNAs), a large class of short noncoding RNAs found in many plants and animals, often act to post-ranscriptionally inhibit gene expression. We report the generation of deletion mutations in 87 miRNA genes in Caenorhabditis elegans, expanding the number of mutated miRNA genes to 95, or 83% of known C. elegans miRNAs. We find that the majority of miRNAs are not essential for the viability or development of C. elegans, and mutations in most miRNA genes do not result in grossly abnormal phenotypes. These observations are consistent with the hypothesis that there is significant functional redundancy among miRNAs or among gene pathways regulated by miRNAs. This study represents the first comprehensive genetic analysis of miRNA function in any organism and provides a unique, permanent resource for the systematic study of miRNAs.
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