Journal
ACCOUNTS OF CHEMICAL RESEARCH
Volume 40, Issue 12, Pages 1412-1419Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ar700167a
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Historically, biocatalytic ketone reductions involved the use of Baker's yeast.,within the last five years, a significant and growing number of isolated ketoreductases have become available that have rendered yeast-based reductions obsolete. The broad substrate range and exquisite selectivities of these enzymes repeatedly outperform other ketone reduction chemistries, making biocatalysis the general method of choice for ketone reductions. Presented here is a summary of our understanding of the capabilities and limitations of these enzymes.
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