Journal
ACTA OTO-LARYNGOLOGICA
Volume 127, Issue -, Pages 113-117Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03655230701599982
Keywords
olfactory neuroblastoma; craniofacial resection; long-term outcome; prognostic factors; Hyams' histopathological grade; Kadish classification
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Conclusions. The progression of olfactory neuroblastoma showed a biphasic pattern. As well as Hyams' histopathological grading and neck metastasis at presentation, early phase recurrence should be regarded as an important prognosticator. A high local failure rate suggests that craniofacial resection followed by postoperative radiotherapy should still be the standard treatment for olfactory neuroblastoma. Objective. The aim of this study was to evaluate factors associated with survival and local control of olfactory neuroblastoma in the long run and to estimate treatment strategies. Patients and methods. Twelve patients (seven men and five women) who had undergone initial curative treatment for olfactory neuroblastoma were retrospectively analyzed. Results. Cause-specific 10-year survival was 64.8%, while disease-free 10-year survival remained 28.6%. Local failure was found in half of the patients. All of the three patients who did not receive radiotherapy developed local failure. A biphasic pattern of recurrence was observed. The early phase recurrence group showed a significantly poorer survival than the late phase recurrence group. Hyams' histopathological grading and neck metastasis at presentation were also correlated with survival.
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