Journal
CHEMISTRY & BIOLOGY
Volume 14, Issue 12, Pages 1315-1322Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2007.10.015
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Funding
- NIGMS NIH HHS [GM59159] Funding Source: Medline
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Here we report the ribosomal polymerization of alpha-hydroxy acids by means of genetic code reprogramming. The flexizyme system, a ribozyme-based tRNA acylation tool, was used to reassign individual codons to seven types of a-hydroxy acids, and then polyesters were synthesized under controls of the reprogrammed genetic code using a reconstituted cell-free translation system. The sequence and length of the polyester segments were specified by the mRNA template, indicating that high-fidelity ribosome expression of polyesters was possible. This work opens a door for the mRNA-directed synthesis of backbone-altered biopolymers.
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