Journal
DEVELOPMENTAL DYNAMICS
Volume 236, Issue 12, Pages 3402-3407Publisher
WILEY
DOI: 10.1002/dvdy.21365
Keywords
spinal cord; oligodendrocyte progenitor; radial glia; zebrafish transgenic; adult neural stem cell
Categories
Funding
- NCI NIH HHS [CA68485] Funding Source: Medline
- NEI NIH HHS [EY08126] Funding Source: Medline
- NICHD NIH HHS [HD15052] Funding Source: Medline
- NIDDK NIH HHS [DK59637, DK20593] Funding Source: Medline
- NINDS NIH HHS [NS046668] Funding Source: Medline
Ask authors/readers for more resources
Continuous production of new neurons and glia in adult mammals occurs within specialized proliferation zones of the forebrain. Neural cell proliferation and neurogenesis is more widespread in adult amphibians, reptiles, and fish but the identity of neural stem cell populations in these organisms has not been fully described. We investigated expression of a reporter gene driven by olig2 regulatory DNA at postembryonic stages in zebrafish. We show that olig2 expression marks a discrete population of spinal cord radial glia in larvae and adults that divide continuously. olig2(+) radial glia have hallmarks of stem cells and their divisions appear to be asymmetric, producing new oligodendrocytes but not neurons or astrocytes. Developmental Dynamics 236:3402-3407, 2007. (c) 2007 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available