Journal
PHYTOMEDICINE
Volume 14, Issue 12, Pages 853-855Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.phymed.2007.06.011
Keywords
antiplatelet activity; piperlongumine; Piper longum L.
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The inhibitory effects of four acidamides, piperine, pipernonaline, piperoctadecalidine, and piperiongumine, isolated from the fruits of Piper longum L. on washed rabbit platelet aggregation were examined. All of the four tested acidamides showed dose-dependent inhibitory activities on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA), and platelet-activating factor (PAF), except for that induced by thrombin. Piperlongumine, in particular, showed stronger inhibitory effects than other acidamides to rabbit platelet aggregation induced by collagen, AA and PAF. (c) 2007 Elsevier GmbH. All rights reserved.
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