Journal
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
Volume 12, Issue 4, Pages E78-E82Publisher
SPRINGER
DOI: 10.1007/BF03327599
Keywords
Cortex; binge eating; eating disorders; cognitive control; conflict; anticipation
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Funding
- General Clinical Research Center (GCRC) at Mount Sinai School of Medicine [M01-RR-00071]
- Network RETICS : Red de Enfermedades Mentales [RD06-0011REM-TAP]
- Junta Extremadura
- Fondo Social Europeo, Spain [MOV06A550]
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INTRODUCTION: Eating disordered patients (EDp) who binge-eat appear to present impulse control deficits that influence treatment outcome. The present bulimia nervosa (BN) study tests the function of brain areas involved in top-down control of behavior, associated with the anterior cingulate cortex (ACC), at the individual level. METHODS: ACC activity was analyzed in two women with BN and one matched control with a reliable and simple cue imperative target paradigm for response anticipation and response conflict processing using an event-related functional magnetic resonance imaging (fMRI) design. RESULTS: Patients showed meaningful ACC patterns of activation, less recruitment for response anticipation, and abnormal for response conflict, when they had to suppress an inappropriate response. DISCUSSION: Preliminary evidence suggests a BN neurocognitive model of impaired executive control-related brain activity. Reliable fMRI paradigms may be clinically useful to determine ACC dysfunction in EDp, to inform treatment and track changes. (Eating Weight Disord. 12: e78-e82, 2007). (C) 2007, Editrice Kurtis
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