Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 9, Issue 8, Pages 1886-1893Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1600-6143.2009.02724.x
Keywords
Antibodies; antibody-mediated rejection; crossmatching; HLA; kidney transplantation
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Funding
- NCRR NIH HHS [UL1 RR025741] Funding Source: Medline
- NIDDK NIH HHS [R01 DK025243] Funding Source: Medline
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A total of 1586 FCXM, performed between June 2007 and September 2008, between all potential deceased donors in our region and sera from patients awaiting kidney or kidney-pancreas transplant, listed at Northwestern Memorial Hospital were evaluated. A key finding of this analysis was the understanding that a thorough vXM cannot be performed in some donor/recipient pairs due to the lack of certain antibody profile data specific to the donor in question. Obtaining more in depth and stringent information regarding antibody specificities, we demonstrate an excellent sensitivity and specificity of the vXM assays- 86.1% and 96.8%, respectively, with a positive likelihood ratio and negative likelihood ratios of 26.9 and 0.14, respectively. The vXM can serve as an outstanding tool to predict HLA compatibility between donor and recipient, with the caveat that the presence/absence of all antibodies against the potential donor and their strength have been thoroughly investigated.
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