Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 9, Issue 12, Pages 2816-2824Publisher
WILEY
DOI: 10.1111/j.1600-6143.2009.02844.x
Keywords
Clinical; islet transplantation; positron emission tomography (PET); 18F-fluorodeoxyglucose ([18F]FDG); instant blood-mediated inflammatory reaction (IBMIR)
Categories
Funding
- Swedish Medical Research Council
- Nordic Insulin Fund
- Ernfors Family Fund
- Barn Diabetes Fonden
- Swedish Diabetes Association
- Juvenile Diabetes Foundation International
- National Institutes of Health
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A fraction of the islets (23%) were labeled with 18F-fluorodeoxyglucose ([18F]FDG) and carefully mixed with unlabeled islets just prior to intraportal transplantation. The peak radioactivity concentration in the liver was found at 19 min after start of islet infusion and corresponded to only 75% of what was expected, indicating that islets are lost during the transplantation procedure. No accumulation of radioactivity was found in the lungs. A nonphysiological peak of C-peptide was found in plasma during and immediately after transplantation in all subjects. Distribution in the liver was heterogeneous with wide variations in location and concentration. Islets found in areas with concentrations of > 400 IEQ/cc liver tissue varied between 1% and 32% of the graft in different subjects. No side effects attributed to the PET/CT procedure were found. Clinical outcome in all patients was comparable to that previously observed indicating that the [18F]FDG labeling procedure did not harm the islets. The technique has potential to be used to assess approaches to enhance islet survival and engraftment in clinical transplantation.
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