Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 189, Issue 2, Pages 190-199Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2007.09.004
Keywords
2D NMR spectroscopy; HSQC; t(1) noise; trace correlation; metabolomics
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The presence of t(1) noise artefacts in 2D phase-cycled Heteronuclear Single Quantum Coherence (HSQC) spectra constrains the use of this experiment despite its superior sensitivity. This paper proposes a new processing algorithm, working in the frequency-domain, for reducing t(1) noise. The algorithm has been developed for use in contexts, such as metabolomic studies, where existing denoising techniques cannot always be applied. Two test cases are presented that show the algorithm to be effective in improving the SNR of peaks embedded within t(1) noise by a factor of more than 2, while retaining the intensity and shape of genuine peaks. Crown copyright (c) 2007 Published by Elsevier Inc. All rights reserved.
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